Moreover, considering that several studies hint at a key role for human GPD1 in cancer metabolism (Zhou et al. 2017; Rusu et al. 2019; Liu et al. 2021; Xia et al. 2021), our findings highlight the need to better understand how this highly studied enzyme influences gene expression, cell growth and differentiation, and metabolic signaling networks. The gene discussed is GPD1; the disease is cancer.