Phenotypically, NK cells from MS donors displayed a more migratory profile than those from control and dementia cases (Figure 3a): higher expression of CD49d (integrin alpha-4), CD54 (ICAM1 or intercellular adhesion molecule 1), and CD31 (PECAM1 or platelet endothelial cell adhesion molecule). The gene discussed is PECAM1; the disease is dementia.