Insulin is a widely usedbiopharmaceutical for diabetes treatment;28 however, on account of limited stability it requires strict storageconditions (e.g., 2–6 °C) as it is prone to form immunogenicfibrillar aggregates in solution.29 Insulinhas an N-terminal phenylalanine, which can serve as a guest for CB[8].30−32 Heteropeptide dimerization of insulin and F′GGGGG-functionalizedresin may offer a promising solution to address insulin instability. Here, INS is linked to diabetes mellitus.