Apart from erythropoietic effects, EPO has regulatory effects upon energy homeostasis, impaired signaling in non‐erythropoietic tissues leading to obesity and IR, and increased EPO levels associated with pre‐eclampsia towards the end of pregnancy (Dey et al., 2020; Gusar et al., 2020; Reinhardt et al., 2016; Teng et al., 2011). This evidence concerns the gene EPO and Obesity.