PRKAA1 and obesity due to melanocortin 4 receptor deficiency: Interestingly, treatment of dams with diet‐induced obesity 1 week before mating and throughout pregnancy with metformin, which mode of action is AMPK activation, improved maternal metabolic health and reduced uterine artery compliance but did not correct placental structure or fetal growth restriction (Hufnagel et al., 2021).