Reactivating Tcf4 expression in excitatory pyramidal neurons, dentate gyrus mossy cells, and granule cells within the dorsal telencephalon, starting from ~E11.5, improved memory, anxiety phenotype, and innate behavior, while reactivating Tcf4 expression in almost all GABAergic neurons throughout the brain at ~E13.5 partially rescued memory and innate behavior (Goebbels et al., 2006; Taniguchi et al., 2011; Figure 2). This evidence concerns the gene TCF4 and Anxiety.