We implanted recording electrodes in the hippocampus, a site of high Tcf4 expression (Kim et al., 2020) and a region in which there is a well-characterized enhancement of long-term potentiation in PTHS model mice (Kennedy et al., 2016; Thaxton et al., 2018), and then recorded LFPs from freely moving mice (Figure 5A and Figure 5—figure supplement 1A-B). The gene discussed is TCF4; the disease is Pitt-Hopkins syndrome.