Within PCOS women, three studies showed no significant change in LH per year (Brown et al., 2011) or from baseline (Carmina et al., 2012b; Ng et al., 2019), while two others indicated significant increases from baseline (Schmidt et al., 2011a; Forslund et al., 2021). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.