Among women with PCOS, seven of the eight studies that compared DHEAS changes from baseline reported significant declines (Brown et al., 2011; Schmidt et al., 2011a; Carmina et al., 2012a,b; Palomba et al., 2014; Udesen et al., 2019; Forslund et al., 2021), but one study showed a non-significant decline (Palomba et al., 2007). The gene discussed is SULT2A1; the disease is polycystic ovary syndrome.