SHBG and polycystic ovary syndrome: Among studies that reported SHBG change from baseline within PCOS women, two reported significant declines (Brown et al., 2011; Udesen et al., 2019), one observed a significant increase (Forslund et al., 2021), and three did not observe a significant change in SHBG levels (Palomba et al., 2007; Schmidt et al., 2011a; Palomba et al., 2014).