To this end, we further compared the clinical data between the three groups and found that the cardiac function indicators of the ischemic group, such as NT‐proBNP, and the proportion of NYHA Class III/IV, were higher than those in the above two groups, while LVEF, 6MWT distance was lower than the above two groups, suggesting that the severity of HF was higher in patients with ischemic HF. The gene discussed is NPPB; the disease is hydrops fetalis.