Whereas SHH medulloblastoma is characterized by an overall deregulation of the SHH signaling pathway, there are also abnormalities specific to patient age (Gibson et al., 2010; Kho et al., 2004; Kool et al., 2014; Northcott et al., 2011; Northcott et al., 2017). The gene discussed is SHH; the disease is medulloblastoma.