As these processes are overrepresented within the older SHH medulloblastoma subtypes, this suggests that the SHH-induced perinatal surge in CGNP proliferation, possibly coinciding with increased DNA damage due to replication stress, is a critical event during cerebellar development that brings along the risk of developing child and adulthood medulloblastoma (Cavalli et al., 2017; Hovestadt et al., 2019; Northcott et al., 2017; Vladoiu et al., 2019). The gene discussed is SHH; the disease is medulloblastoma.