Adipose tissue‐derived adiponectin, the most abundant and well‐studied peptide, is considered a therapeutic molecule regarding the multiple effects in metabolic disorders such as obesity and diabetes that serves a dominant protective role in endothelial dysfunction reflecting appreciable anti‐atherogenic, insulin‐sensitizing and anti‐inflammatory effects in both pre‐clinical and clinical settings.19 The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.