We also show here that multiple human cell lines derived from osteosarcoma, a rare pediatric cancer, were particularly sensitive to (S)-DACs (Figure 1—figure supplement 4C), suggesting that HSD17B11- and more generally SDR-bioactivable prodrugs could find anticancer applications, especially considering that 71 different SDRs are found in humans (Bray et al., 2009). Here, HSD17B11 is linked to cancer.