Studying SHP2-driven JMML(-like MPN) during fetal hematopoiesis is challenging in conditional knock-in mouse models of JMML with PTPN11 mutations, because mutant SHP2 expression is induced only postnatally (Chan et al., 2009; Xu et al., 2011) or indolent MPN is induced (Tarnawsky et al., 2017; Tarnawsky et al., 2018). This evidence concerns the gene PTPN11 and juvenile myelomonocytic leukemia.