Based on the crucial roles of the nine prognosis‐related DEGs in PCa, we calculated the age‐ and TME‐related risk score (ATRS) of each TCGA‐PRAD samples by Cox regression analysis, and the ATRS was expressed as follows: ATRS = (EPYC expression * 0.770043013606353) + (FAM163B expression * 2.83200842600699) + (INSL5 expression * −0.201150270317484) + (SUCNR1 expression * 0.197919534424295) + (SCRT1 expression * 0.136292272605538) + (DPEP1 expression * ‐1.0685300492505) + (KLHL1 expression * −1.87610207246247) + (LY6G6C expression * −0.880214755865202) + (PNMA5 expression * −0.112025054006857). Here, INSL5 is linked to prostate adenocarcinoma.