Hsa_hsa_circ_0000285, a circRNA generated from homeodomain interacting protein kinase 3 (HIPK3), suppresses the progression of various cancers, including cervical cancer,18 osteosarcoma,19, 20 thyroid cancer,21 and hepatocellular carcinoma.22 The gene discussed is HIPK3; the disease is hepatocellular carcinoma.