The multivariate Cox regression analysis exhibited that the prognosis score was an independent prognostic indicator for OS in HCC patients from the TCGA cohort (Table 2) and the ROC curve analysis revealed that the NMRG signature had the highest sensitivity and specificity in predicting the OS of HCC patients, compared with clinic-related features, including AFP, VI, histological grading, and TNM clinical stages (Figures 7(a)–7(c)). The gene discussed is AFP; the disease is hepatocellular carcinoma.