VEGFA and endothelial dysfunction: VEGF-Pi3k-Akt-eNOS pathway activation can improve endothelial dysfunction and restore cardiac diastolic capacity (Wang et al., 2010; Couto et al., 2018; Palabiyik et al., 2019), but it has also been reported that different exercise contents will have different regulations on the expression of PI3K pathway signal protein even if the exercise type and exercise time are similar (Song et al., 2015).