In conclusion, blood flow-restricted low resistance training can activate the VEGF-Pi3k-Akt-eNOS pathway, upregulate the expression of VEGF and eNOS, promote myocardial microvascular circulation, improve cardiac function, lower blood pressure and achieve the preventive effect of early hypertension, and the hypotensive effect is better than traditional resistance training. This evidence concerns the gene AKT1 and hypertensive disorder.