In conclusion, blood flow-restricted low resistance training can activate the VEGF-Pi3k-Akt-eNOS pathway, upregulate the expression of VEGF and eNOS, promote myocardial microvascular circulation, improve cardiac function, lower blood pressure and achieve the preventive effect of early hypertension, and the hypotensive effect is better than traditional resistance training. The gene discussed is AKT1; the disease is Hypertension.