Hypoxia-inducible factor 1-alpha (HIF1A) is the main transcriptional regulator of the adaptive response to hypoxia, which is related to metastasis of various tumor cells and poor prognosis of cancer patients [55, 56], including sarcoma [57, 58], advanced renal cell carcinoma (RCC) [59], breast cancer [60], and NB [61–63]. Here, HIF1A is linked to neuroblastoma.