GSDME and neoplasm: Among these ELANE, NLRP6, CASP4, SCAF11, PRKACA, CASP6, CASP9, AIM2, NLRP7, GPX4, NOD2, TIRAP, PJVK, CASP3, NOD1, CASP8, GSDMD, NLRP1, GSDME, GSDMB, PYCARD, PLCG1, and GSDMC were upregulated in tumor than normal, while IL6, IL1B, and NLRP3 were downregulated (Figure 1).