The following variables had been associated with an extended chance of TERT promoter mutation in PTC patients: age < 45 years (MD = 10.93, 95%CI = 7.25–14.61); gender = male (pooled OR = 1.63, 95%CI = 1.17–2.28); tumor size > 1 cm (MD = 0.56, 95%CI = 0.34–0.77); lymph node metastasis (pooled OR = 1.29, 95%CI = 0.93–1.79); vascular invasion (pooled OR = 1.78, 95%CI = 0.83–3.84); extrathyroidal extension (pooled OR = 2.00, 95%CI = 1.32–3.02); distant metastasis (pooled OR = 1.46, 95%CI = 1.04–2.04); advanced TNM stage (pooled OR = 3.19, 95%CI = 2.28–4.45). This evidence concerns the gene TERT and neoplasm.