Age (> 45 years), gender (=male), tumor size (>1 cm), LNM, vascular invasion, ETE, distant metastasis, and advanced TNM stage (stages III and IV) were finally considered to be the risk factors of TERT promoter mutation in PTC patients while multifocality was not correlated with TERT promoter mutation in PTC patients. This evidence concerns the gene TERT and neoplasm.