We observed that the PCMT1 gene was significantly up-regulated in 10 tumors including colon adenocarcinoma (COAD, tumor: 5.57 ± 0.42; normal: 5.44 ± 0.19, P = 8.4e − 4) and breast carcinoma (BRCA, tumor: 6.04 ± 0.60; normal: 5.79 ± 0.20, P = 9.8e − 11) (Figure 1(a)). The gene discussed is PCMT1; the disease is colon adenocarcinoma.