We selected ten genes that were both differentially methylated and differentially expressed in atherosclerotic carotid plaques, including COL1A1, THBS2, RGS5, PRKCB, MYH10, FGF2, WNT2B, ETS1, CD8A, and EGFR, to explore their expression changes in atherosclerosis patients. The gene discussed is RGS5; the disease is atherosclerosis.