By performing IF and FISH assays, we observed colocalization of endogenously expressed circZNF609 and FMRP protein in the cytoplasm of cutaneous melanoma and acral melanoma cells (Fig. 5b, c), suggesting that circZNF609 might associate with FMRP to perform its function. The gene discussed is FMR1; the disease is acral lentiginous melanoma.