RAC1 and cutaneous melanoma: Moreover, we found that the expression of RAC1 mRNA was positively correlated with the copy number values of skin cutaneous melanoma patients from TCGA database (Fig. 7d, e), and the group with the highest RAC1 expression, named the RAC1 amplification group, had significantly worse OS and DFS than the nonamplification group (Fig. 7f, g).