Moreover, we extracted the transcriptome data of 34 patients with acral melanoma from Liang’s cohort through the cBioPortal database [39, 40] and found a negative correlation between FMRP mRNA and RAC1 mRNA (Fig. 6h), further confirming that FMRP is involved in regulation of RAC1 nontranslational pathways in melanoma. The gene discussed is FMR1; the disease is melanoma.