Overexpression of miR-143-3p significantly downregulated the expression of HK2, LDHA and PKM2 in the blank + miR-143 mimic group compared to the blank group (Fig. 6B, D–F), while knockdown of miR-143-3p upregulated the expression of HK2, LDHA and PKM2 in the PCOS + miR-143 inhibitor group compared to the PCOS group (Fig. 6C–F). The gene discussed is HK2; the disease is polycystic ovary syndrome.