TARDBP and Stroke: Moreover, there is the complicating impact of other concomitant neurodegenerative processes (including those marked by inclusions containing alpha-synuclein and TAR DNA-binding protein 43 (TDP-43)) and vascular brain lesions (including small vessel disease such as arteriolar sclerosis and cerebral amyloid angiopathy (CAA), as well as stroke) whose prevalence also increases with age [6, 25, 46].