In agreement with the results above, we also found that total number of oligodendrocytes (Olig2) and total microglial (IBA1) cell numbers and burden in WM remained unchanged across groups regardless of presence and/or absence of tau deposition in the immediately adjacent cortex (Fig. 3), further reinforcing the idea of qualitative rather than quantitative glial changes in demented AD brains. This evidence concerns the gene AIF1 and Alzheimer disease.