We first evaluated the expression of KDM4A, KDMB, and KDM4C in several prostatic epithelial lines: the immortalized prostatic epithelial line RWPE1, the androgen-dependent PCa line LNCaP, and the AR-positive CRPC lines C4-2, C4-2B, VCaP, and CWR22Rv1. The gene discussed is KDM4C; the disease is posterior cortical atrophy.