Moreover, we noticed that there was a significant difference in the expression of multiple immune cell types between the T1D and no-T1D groups (Fig. 2A), including activated CD8 T cells, immature dendritic cells, mast cells, regulatory T cells, type 1 T helper cells, and type 17 T helper cells (P < 0.001). Here, CD8A is linked to type 1 diabetes mellitus.