The study by Xu et al. shows that ADM can enhance the migration and invasion of myelomonocytic cells by activating multiple signaling pathways, including MAPK, PI3K/Akt, and eNOS in pancreatic cancer, as well as promote myelomonocytic cells trans-endothelial migration through increased expression of VCAM-1 and ICAM-1. The gene discussed is VCAM1; the disease is pancreatic neoplasm.