Furthermore, the univariate Cox regression analyses indicated that overexpression of PAFAH1B3 (HR = 2.240, P = 0.019, 95% CI = 1.141–4.394), advanced TNM stage (HR = 1937, P < 0.001, 95% CI = 1.431–2.621), distant metastasis (HR = 6.014, P < 0.001, 95% CI = 3.086–11.72) and lymph node metastasis (HR = 3.389, P < 0.001, 95% CI = 1.824–6.297) were prominent negative prognostic factors for patients with LUAD (Table 2). Here, PAFAH1B3 is linked to metastatic malignant neoplasm in the lymph nodes.