When the 7 ASMD patients were referred to our hospital for subspecialty evaluations, all had hepatosplenomegaly and elevated aspartate aminotransferase (AST) with the ratios of AST to alanine aminotransferase (ALT) ranging from 0.9 to 10.7 (Table 2). The gene discussed is GPT; the disease is Hepatosplenomegaly.