Martinez-Garcia et al. reported that overexpression of MMSET is correlated with an increase in lysine 36 methylation of histone H3 (H3K36me2) and a decrease in lysine 27 methylation of histone H3 (H3K27me2) across the genome in MM cells, which affects cell adhesion, growth, and survival [56]. Here, NSD2 is linked to Miyoshi myopathy.