CHI3L1 levels (ng/mL) predict transfer to ICU or death independent of HTN, COPD, CAD, DM, active neoplasia, CKD, NLR at admission, hospitalization, length of stay in hospital, steroid therapy and LMWH administration during hospitalization (Supplementary Table 1). The gene discussed is CHI3L1; the disease is chronic obstructive pulmonary disease.