From our big data pan-cancer studies, among the identified hub genes (protein-coding), FN1, CD44, TIMP1, SNAI2, and SPARC were found to be common hub nodes between co-expression and PPI networks across multiple drugs, and these genes were significantly enriched in signal transduction, and PI3K/Akt-signaling pathway, among others. The gene discussed is SPARC; the disease is cancer.