CDKN2A and cervical squamous intraepithelial neoplasia: A retrospective study of a large number of cases of cervical squamous intraepithelial lesions showed that approximately 15% of patients with p16-positive LSIL immunohistochemistry would progress to HSIL, whereas 9.4% of patients with p16-negative LSIL immunohistochemistry would progress to HSIL.