ATP5IF1 and central nervous system cancer: Interestingly, whereas the overexpression of IF1 in hepatocarcinomas [51, 52], gliomas, and in bladder and gastric carcinomas is pro-oncogenic (for review see [53]), multivariate analysis indicated that an increased content of IF1 in LUAD (this study), colon [31] and breast [54] carcinomas offers an independent marker of good prognosis, emphasizing the context dependency of some mitochondrial proteins in oncogenesis [55].