IDH1 and neoplasm: The tumor content of the proteins involved in the antioxidant response glucose-6-phosphate dehydrogenase (G6PDH), glutathione reductase (GR), superoxide dismutase 1 and 2 (SOD1 and SOD2), catalase, peroxiredoxin 2, 3 and 6 (PRX2, PRX3, PRX6), NADP+-dependent isocitrate dehydrogenase 1 (IDH1) and thioredoxin (TRX) were significantly augmented when compared to its content in NAT (Fig. 3a).