ZNF334 and cancer: To verify whether ZNF334 promoter was hypermethylated during the inflammatory-to-cancer transformation process, we constructed a DEN-induced carcinogenesis mice model (Fig. 2B) and examined the DNA methylation level of ZNF334 (also called Zfp334 in mice) promoter at different time point after CCl4 injection (2w, 4w, 8w, 12w, and 18w after first CCl4 injection, respectively).