ERBB2 and triple-negative breast carcinoma: Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and lack of overexpression at the plasma membrane (PM) of ErbB-2/HER2 (MErbB-2), a member of the ErbB family of tyrosine kinase receptors, or of ERBB2 gene amplification.