BECN1 and cardiac hypertrophy: Beclin1 and Atg5 are two autophagy-related (Atg) proteins, however they show a different result between Becn1+/− mice with alleviative myocardial remodeling and Atg5+/− mice with aggravating myocardial hypertrophy in pathological myocardial remodeling [144, 145].