NEFL and Sepsis: On day one the mean plasma concentration of NfL was 76.5 pg/ml (SD 79.0) in patients without sepsis and 120.8 pg/ml (SD 140.2) in patients with sepsis, p-value 0.006, and for day 3 100.8 (100.2 without sepsis and 221.2 (342.1) with sepsis, p-value <0.001 (Table 3).