also positively correlated with elevated levels of inflammatory cytokines (IL-1ß, IFN-ɣ, TNF-α, IL-8) and immunoglobulin A in the saliva in patients with autoimmune liver disease [40] and in patients with inflammatory bowel disease (dominant genera: Streptococcus, Prevotella, Neisseria, Haemophilus, Veillonella and Gemella correlating to increased IL-1ß and lysozyme levels) [41]. This evidence concerns the gene TNF and inflammatory bowel disease.