RGLS4326binds to miR-17 microRNAs, inhibits miR-17 activity, and reduces diseaseprogression.222 Immunoglobulin A (IgA)nephropathy is a chronic kidney disease that is caused by depositsof protein IgA inside the glomeruli of the kidneys.223 Overproduction of complement factor B (FB) is associatedwith increased IgA nephropathy. This evidence concerns the gene CFB and chronic kidney disease.