Garcia et al reported distinct Gli1 and HoxB6 fibroblast lineages in the healthy mouse pancreas, which can both contribute significantly to KF (Ptf1aFlpO/+;KrasFSF‐G12D/+) and KPF (Ptf1aFlpO/+;KrasFSF‐G12D/+;Trp53FRT‐STOP‐FRT/+)‐driven tumour CAFs, with Gli1+ cells dominating [68]. This evidence concerns the gene GLI1 and neoplasm.