ACTA1 and neoplasm: In contrast, iCAFs are found distal to tumour cells within the stroma and display low α‐SMA expression with upregulation of JAK/STAT and nuclear factor kappa B (NFκB ) signalling, accompanied by secretion of inflammatory cytokines including interleukin‐6 (IL‐6), leukocte inhibitory factor (LIF), and CXCL1 [29, 47].