Using a combination of human samples and orthotopic KPC (Pdx1‐Cre;KrasLSL−G12D/+;p53fl/+)‐derived murine models, as well as lineage tracing, a subpopulation of tumour restraining CAFs expressing Meflin (mesenchymal stromal cell‐ and fibroblast‐expressing Linx paralogue; a glycosylphosphatidylinositol‐anchored protein) have also been described in PDAC [37], which appear to cause alterations to collagen matrix layout. Here, PDX1 is linked to neoplasm.