Each of these four SNPs—rs209421 (UBE3D), rs2816985 (NR5A2), rs2268657 (GLP1R) and rs1772945 (OPRM1)—influences BMI during infancy, with minimal effect on birth weight or subsequent BMI, and no direct association with MS risk (association p values all > 0.05). Here, UBE3D is linked to myeloid sarcoma.