Importantly, the finding of T22-PE24-H6 pyroptotic induction, mediated by activation of the inflammosome marker NLRP3, followed by caspase-1 cleavage and GSDMD cleavage that translocate to the membrane in CRC models, in the absence of apoptosis activation (in sharp contrast with the observation of potent apoptosis induced by the same nanotoxin in a DLBCL lymphoma model (Falgàs et al., 2020) reinforces its use to induce anticancer activity in tumors with inactivated apoptotic pathways, at least in CRC and other solid tumors, especially after recurrence or active metastatic dissemination. The gene discussed is GSDMD; the disease is colorectal carcinoma.