CASP3 and colorectal carcinoma: It is also highly relevant to point out that T22-PE24-H6 induces a mechanism of pyroptosis not previously described in CRC and different from that induced by currently used chemotherapeutic anticancer drugs, which is mediated by activation of caspase-3 and GSDME (Wang et al., 2017; Aizawa et al., 2020).