Once we demonstrated that the T22-PE24-H6 nanotoxin has a potent antitumor effect, mediated by pyroptotic cell death induction, in CXCR4+ SW147 subcutaneous tumors, we performed an experiment to determine its capacity to prevent cancer cell dissemination and metastatic foci growth at the clinically relevant organs affected by metastases in an orthotopic CXCR4+ SW1417 CRC model. The gene discussed is CXCR4; the disease is cancer.