After exposure of CXCR4+ SW1417 cells to the T22-PE24-H6 nanotoxin for a short time, at 2 or 5 hours, we found in almost all cancer cells a high overexpression of the NLRP3 protein, an inflammatory marker that initiates the signaling cascade that leads to pyroptosis. The gene discussed is NLRP3; the disease is cancer.