GSTM1 and sickle cell disease: Sickle cell disease (SCD) is an autosomal-recessive genetically transmitted haemoglobinopathy that is responsible for considerable morbidity and mortality.1 Sickle cell disease results from a point mutation in the gene, a substitution of glutamic acid with valine at position six of the haemoglobin beta chain, causing an abnormality in haemoglobin synthesis, leading to the production of red blood cells that have an abnormal sickle shape.2 The different forms of SCD include sickle cell anaemia (haemoglobin SS [HbSS]), sickle cell haemoglobin C (Hb-SC) and sickle cell thalassaemia (Hb-SSthal).2