PRTN3 and pemphigus foliaceus: These SNPs were, as we have shown, significantly associated with PF in this patient cohort (Table 1, and ref. [12]). In the multiple variable models (adjusted for sex, age, ever smoker status, methotrexate at index date and RF status) and including each separately of the three SNPs, antibodies against Vim60–75, Fibβ62–78 (72) and F4-CIT-R and the number of ACPA specificities remained significantly associated with PF development (Table 2; P < 0.001 to P < 0.05).