VTN and cancer: Additionally, increased vitronectin synthesis and elevated levels of integrin β5 correlate with disease progression of different types of cancer, including colorectal, brain, breast and non-small cell lung cancer (Gladson et al., 1997; Uhm et al., 1999; Bianchi-Smiraglia et al., 2013; Bai et al., 2015; Vogetseder et al., 2013; Schittenhelm et al., 2013; Tomasini-Johansson et al., 1994).