NCKAP1L and Splenomegaly: In addition, Hem-1–deficient children often present with signs of hyperinflammation, including increased ferritin and soluble IL-2 receptor, liver calcification (20), splenomegaly, gastroenteritis, and hemophagocytic lymphohistiocytosis (20, 22), which collectively contribute to growth abnormalities and failure to thrive.