CD21–/loCD11c+CXCR3+ ABC cells expressing T-bet are increased in SLE (64, 65), Crohn’s disease (66), Sjogren’s syndrome (67), rheumatoid arthritis (52), common variable immunodeficiency (68, 69), and multiple sclerosis (70). This evidence concerns the gene CXCR3 and systemic lupus erythematosus.