NCKAP1L and lymphopenia: Similarly, mice with a noncoding point mutation in Nckap1l (Hem1) are severely immunodeficient, characterized by defective T cell activation, T and B cell lymphopenia, hemolytic anemia, dysregulated cytokine production, defective phagocytosis by macrophages, neutrophil migration defects, failure to thrive, and autoimmunity (23, 24).