The increased VTN‐driven inflammation seen in the female mouse injured brain would also be consistent with the findings that the vagus nerve has anti‐inflammatory activity in a number of disease models (Bonaz et al., 2016; Hoover, 2017), including stroke (Ay et al., 2016; Cai et al., 2014; Cheyuo et al., 2011). This evidence concerns the gene VTN and stroke disorder.