In mice, VTN is detrimental after ischemic stroke only in females (Jia, Malone, et al., 2020) by further increasing expression of the pro‐inflammatory cytokine IL‐6 (Keasey et al., 2018), inflammation (Milner et al., 2007) and tissue injury (Jia, Malone, et al., 2020) in the brain. This evidence concerns the gene VTN and ischemic stroke.