Till date, 20 DUBs were identified in L. mexicana, which mainly belong to seven structural super families, ubiquitin-specific proteases (USPs, family C19), C-terminal hydrolyases (UCHs, family C12), ovarian tumor proteases (OTUs, family C65), JAB1/MPN/MOV34 metalloenzymes (JAMM/MPN+, family M67), Josephins (family C86), MINDY (family C115), and ZUFSP (zinc finger with UFM1-specific peptidase domain protein, family C78) [113]. The gene discussed is ZUP1; the disease is ovarian neoplasm.