In support of the notion that OSM adds to adipocyte and metabolic dysfunction, OSM was shown to induce adipokines associated with insulin resistance and inflammation such as IL-6, plasminogen activator inhibitor-1 (PAI-1), and monocyte chemotactic protein‐1 (MCP-1) in cultured adipocytes [6,7,10]. This evidence concerns the gene SERPINE1 and Insulin resistance.