In this paper, we aim to analyze plasma Gas6, sAxl, and sMerTK levels in a prospective cohort of hospitalized SARS-CoV-2 positive patients that underwent standard therapy (corticosteroids and heparin) to evaluate if Gas6 and/or TAM levels measured at hospital admission and during hospitalization may predict COVID-19 in-hospital trajectory as well as treatment response. This evidence concerns the gene GAS6 and COVID-19.