GPT and Hand-foot syndrome: Furthermore, the adverse reactions with grades 3-4 were in the following: fatigue (10.3%), nausea and vomiting (12.8%), diarrhea (7.7), hypertension (12.8%), HFS (10.3%), rash (5.1), AST/ALT elevation (5.1%), proteinuria (5.1%), and RCCEP (2.6%).